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full spectrum of non-clinical model systems of the liver cryopreservation plateablerodent hepatocytes liver subcellular fractions fluorescent transporter probes clearance prediction in special populations transporter-based pharmacokinetic boosting unbound concentration assessment in vitro model for identification of drug candidates showing risk for drug-induced cholestasis bile acid profiling in silico models for structure-based prediction of transporter inhibition Bioanalytical activities


Pharmacometrics is the science of applying mathematical/statistical methods to amenable questions in drug development and therapy. Although a relatively young science (the name appeared first in 1982), it dates back to Widmark, Teorell and Dost, many decades earlier. However, only with the availability of (relatively) user-friendly software for nonlinear mixed effects modeling and affordable and powerful hardware, the specialty gained widespread application and recognition, as well as a much broader scope after 1990. At the drug delivery and disposition unit, Pharmacometrics was established as independent specialtyin 2016 and focuses on the application of parametric (NONMEM) and nonparametric (Pmetrics) methods for parameter identification and simulation (Berkeley Madonna, Pmetrics). Applications range from the quantitative description of drug metabolism in cell culture systems to the optimization of dosing regimens in patients across multiple therapeutic areas. An ongoing area of research is the optimization of dose finding methods and making computer assisted dose finding available to physicians without pharmacometric training at the point of care. We also offer in-house consulting to clinicians studying the dosing regimen-exposure-response relationship of drugs.

Pharmaceutical Technology

The study of formulation strategies and manufacturing processes is the research topic of the Pharmaceutical Technology research group of Drug Delivery and Disposition. The aim is to correlate the physical structure of the drug delivery system to the drug release kinetics and stability profile, and to correlate formulation and processing parameters tot he resulting physical structure. The group is worldwide recognized for expertise in the field of amorphous materials and solid (molecular) dispersions of poorly soluble drugs.

Quartiles are useful, but they are also somewhat limited because they do not take into account every score in our group of data. To get a more representative idea of spread we need to take into account the actual values of each score in a data set. The absolute deviation, variance and buty sneakers nike air jordan flight pants
are such measures.

The absolute and mean absolute deviation show the amount of deviation (variation) that occurs around the mean score. To find the total variability in our group of data, we simply add up the deviation of each score from the mean. The average deviation of a score can then be calculated by dividing this total by the number of scores. How we calculate the deviation of a score from the mean depends on our choice of statistic, whether we use absolute deviation, variance or nike new air max 2018 red

Perhaps the simplest way of calculating the deviation of a score from the mean is to take each score and minus the mean score. For example, the mean score for the group of 100 students we used earlier was 58.75 out of 100. Therefore, if we took a student that scored 60 out of 100, the deviation of a score from the mean is 60 - 58.75 = 1.25. It is important to note that scores above the mean have positive deviations (as demonstrated above), whilst scores below the mean will have negative deviations.

To find out the total variability in our data set, we would perform this calculation for all of the 100 students' scores. However, the problem is that because we have both positive and minus signs, when we add up all of these deviations, they cancel each other out, giving us a total deviation of zero. Since we are only interested in the deviations of the scores and not whether they are above or below the mean score, we can ignore the minus sign and take only the absolute value, giving us the absolute deviation . Adding up all of these absolute deviations and dividing them by the total number of scores then gives us the mean absolute deviation (see below). Therefore, for our 100 students the mean absolute deviation is 12.81, as shown below:

absolute deviation

Another method for calculating the deviation of a group of scores from the mean, such as the 100 students we used earlier, is to use the variance. Unlike the absolute deviation, which uses the absolute value of the deviation in order to "rid itself" of the negative values, the variance achieves positive values by squaring each of the deviations instead. Adding up these squared deviations gives us the sum of squares, which we can then divide by the total number of scores in our group of data (in other words, 100 because there are 100 students) to find the variance (see below). Therefore, for our 100 students, the variance is 211.89, as shown below:

Easter Pies! Place your order today!

Here’s our 2018 Easter menu – all pies are 10″ and $28.

Lemon Meringue Banana Cream Mixed Berry Classic Apple Apple Crumb Chocolate Cream Cherry Crumb Key Lime Chocolate Bourbon Pecan Coconut Cream Strawberry Rhubarb (either oat crumb or pastry top) Roasted Veg Goat Cheese Bacon, Leek Gruyere Spinach Ricotta with Pine nut Parmesan

Place your order by Wednesday, March 28th for pick up at any Petsi Pies location either Saturday, March 31st or on Sunday, April 1st at our Somerville location until 12PM or our Putnam Ave location until 5PM. We will not be delivering pies on Easter.

Place your order by Wednesday, March 28th

Call any of our locations or stop by to place your order today!

Order your Pi Day pies today! Call the bakery to place your order for pick up at any one of our shops.

Special menu for Pi Day – only 10″ pies ($28 ea)

Lemon Meringue Banana Cream Blueberry Classic Apple Apple Crumb Salted Caramel apple Cherry crumb Mixed Berry Key Lime Chocolate Bourbon Pecan Pecan Miss Mud Pumpkin

We can deliver – but please note that cream and meringue pies do not travel well!


Mardi Gras is early this year – FEBRUARY 13th!

Place your order by Sunday, February 11th for this traditional Mardi Gras treat.

If you would to place an order, please call the bakery on Beacon Street. Like with special pie orders, 48 hour notice is needed.

For the BEST Mardi Gras celebration in town, go to Louisiana-style southern restaurant, Tupelo, to do it in style. Gumbo, award-winning fried chicken, and a special Mardi gras menu.

Petsi Pies bakery in Somerville will be closing at 4pm on Christmas eve and reopening again on December 26 at 7am.

Petsi Pies, East Cambridge, will close at 1pm on Christmas eve and reopen the following weekend on Saturday, 12/30 at 8am.

Petsi Pies on Putnam Ave will close Christmas eve at 4pm andreopen the following weekend on Saturday, 12/30 at 8am.

May you have a happy holiday with family and friends and PIE!

Hurry up! Pies for pick up just before Christmas need to be ordered by tomorrow, December 20th. Happy Holidays!

Here’s our 2017 holiday pie menu – all pies are 10″ and $28.


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